Primary adhesive capsulitis is a subject of much debate. The specific causes of this condition are not
yet known. Possible causes include changes in the immune system, or biochemical and hormonal
imbalances. Diseases such as diabetes mellitus, and some cardiovascular and neurological disorders
may also be contributing factors. In fact, patients with diabetes have a three times higher risk of
developing adhesive capsulitis than the general population. Primary adhesive capsulitis may affect
both shoulders (although this may not happen at the same time) and may be resistant to most forms
of treatment.
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